The crash happened around 6:35 a.m. at Mission Gorge Road and state Route 125, said Lt. Gary Steadman of the San Diego County Sheriff's Department.
One victim died at the scene while the injured person was rushed to a hospital, Steadman said.
Their vehicle struck a berm and went off the roadway into a dirt construction area, he said.
On Aug. 28, CHP Officer Mark Saylor, his wife Cleofe, daughter Mahala and brother-in-law Chris Lastrella were killed in a fiery crash in the same area.
Investigators believe the accelerator of a Lexus sedan loaned to Saylor by an El Cajon dealership became stuck as the vehicle traveled downhill on northbound 125 and went more than 100 mph through the T-intersection at the foot of the Mission Gorge Road offramp, landing in the bed of the San Diego Riv