Don Hooton knows all about performance enhancing drugs. His son Taylor used them, and when he stopped, he became depressed and committed suicide in July 2003.

Fast forward almost 6 years and Don says he's not surprised that Ramirez tested positive. He says it's a sign that baseballs testing program is working.

"They just landed them a giant fish, that they like everybody else probably wish they wouldn't have landed, but he tested positive and he's been suspended for 50 games."

After Taylors death, Don formed the Taylor Hooton Foundation, a program designed to spread the word that performance enhancing drugs are dangerous. Hooton says he doesn't buy Ramirez's excuse that his doctor prescribed the drug.

"There is a procedure for having the drug tested and making sure it's not on the list or if there are legitimate reasons to use a drug like this, to get a waiver."

From 1973 to 1990, Ken Locker was the Dallas Cowboys trainer, now he's the head of athletic training at Texas Health Dallas. He says players have always tried to get an edge. Some believe the drug Ramirez tested positive for, Human Chorionic Gonadotropin, can be used by steroid users after they complete cycles to get their bodies to produce testosterone naturally again.

"You are basically replacing testosterone that you produce with outside." Locker says. "And the body says, so why do I have to produce it? You are going to give it to me so you have things like impotence, you also have things like cancer."

As for Don Hooton, he didn't believe Rafael Palmeiro when he testified before congress in March, 2005.

"Let me start by telling you this." Palmeiro said. "I have never used steroids. period."

And he doesn't believe Manny now.

"I mean you would think they got it in their morning bowl of Wheaties that they had for breakfast that morning, what the general public is learning finally, we're not idiots guys."