Keith Price threw four touchdown passes and Washington scored on all six of its first-half possessions to hand Colorado its 21st consecutive road loss, 52-24, Saturday.
Washington (5-1, 3-0 Pac-12) posted its highest point total in 10 years and became the first team in school history to record at least 30 points in its first six games
The Huskies racked up 379 yards in the first half en route to a 38-10 lead, including 230 yards on 18-of-23 passing by Price, whose touchdowns went to four different receivers. Washington totaled 562 yards in the game.
Price leads the Pac-12 with 21 touchdown passes and is on pace to shatter Cody Pickett's school record of 28 set in 2002.
Colorado (1-6, 0-3 Pac-12) has been outscored 131-58 in its Pac-12 games.
The Huskies' Chris Polk rushed for 117 yards and added a 14-yard touchdown catch. He has 16 career 100-yard rushing games, one shy of Napoleon Kaufman's school record.
Running back Rodney Stewart, who had 60 of Colorado's 77 total yards in the first quarter, left with a right leg injury before halftime and did not return.
Washington freshman quarterback Nick Montana, son of Pro Football Hall of Famer Joe Montana, entered late and was sacked and lost the fumble on his first career snap. He finished 2-of-2 passing for 10 yards.
Freshman Tony Jones scored his first two career rushing touchdowns - both in the second half - for Colorado, which last won on the road 31-26 at Texas Tech in 2007.
Washington last scored 50 points when it defeated Idaho 53-3 on Sept. 22, 2001.