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Nicollette Sheridan, Katherine Heigl, T.R. Knight

TelevisionKatherine HeiglT.R. Knight
ABC stars fly the coop Well, except for this guy, and no one cares if he comes or goes, right? Not when central characters -- Edie on "Desperate Housewives" and Izzie and George on "Grey's Anatomy" -- are really leaving! (Or are they?) Now if they said "Brothers & Sisters" sibling Kevin... Getty Images / Associated Press / Associated Press
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