USC led California, 41-32, on Wednesday night as the Trojans sought their first Pac-12 Conference victory this season.
Forward Byron Wesley and center Omar Oraby led USC with nine points each at the Galen Center.
Cal was led by freshman guard Jordan Matthews, who had 13 points.
The Golden Bears entered the game with a 5-0 record in Pac-12 play. USC is 0-5.
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