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'Malcolm in the Middle' (2000-2006)

Bryan Cranston
Who they are: Gifted youngster Malcolm, played by Frankie Muniz, is the voice of sanity in a dysfunctional family in the half-hour show, which won seven Emmys and was nominated for seven Golden Globes. Jane Kaczmarek plays the strict mother and Bryan Cranston, the boyish father. Malcolm has a... Chris Cuffaro / FOX