The manner in which the Sox generated their offense was even a greater surprise.
"It feels awesome," said Anderson, who will start in Sunday's series finale.
Anderson, making his second consecutive start in center field, helped the Sox equal their highest run total in an inning this season.
Anderson gave hitting coach Greg Walker a hug after reaching the dugout as the Sox (18-17) won their third consecutive game.
Four of Anderson's 11 career home runs have been hit at Safeco Field, with the other seven at U.S. Cellular Field.
"He's handled himself well," manager Ozzie Guillen said. "I don't want to touch the lineup too much."
Vazquez had received a total of three runs of support in his previous three games. Vazquez (4-3) pitched to two batters over the minimum through the first five innings but allowed three runs in the sixth and was pulled after loading the bases.
Octavio Dotel stopped the rally by inducing Kenji Johjima to pop to second.
Those runs loomed larger because of the Mariners' sixth-inning rally.
Meanwhile, Jim Thome has heard the whispers that his slow start could mark the beginning of the end of his storied career.
"I just think that's going to be very common," Thome said before the game as he was out of the lineup to rest. "It's always out there. You have to block that out."
Thome will start the next five games until the Sox visit San Francisco for an interleague series.
"I don't want to sit this guy for three days," said Guillen, adding that Thome will start one of the San Francisco games at first base.
Despite hitting his seventh homer Friday, Thome is batting .218 with 38 strikeouts.
"You want to think you're contributing in some way," Thome said. "It's a long haul. I've had some Aprils and beginning of Mays where I haven't done well.
"But you don't want to say, 'Well, I've had those, and it's going to turn around.' At the same time, it's such a long haul and you have to keep grinding."
Thome, who has collected as many of his home run balls since hitting his 500th last September, said he believes a broken-bat single can be just as helpful as the home run he hit off Carlos Silva in breaking out of a slump.
"You can't go from .200 to .300 overnight," Thome said.
Konerko triggered the Sox's six-run second with an opposite-field single.
Swisher, who took early batting practice against Kevin Hickey and Robin Ventura, hit a two-out RBI triple in the fifth. Quentin added an RBI single in the ninth.Copyright © 2015, The Baltimore Sun